当センターは世界最大級のリウマチセンターであり、最新の研究活動とその結果得られる最新情報の発信は我々に与えられた重要な使命の一つと考えております。これまでにIORRAコホートや病棟で蓄積された数多くの症例を背景とした臨床研究、多彩なフィールドでの基礎研究などで多くの業績をあげており、また世界最大級の患者数を誇る施設であるため、貴重な症例の報告も積極的におこなっています。
関節リウマチ
1. Sugimoto N, Tanaka E, Inoue E, Abe M, Sugano E, Sugitani N, Saka K, Ochiai M, Higuchi Y, Yamaguchi R, Ikari K, Nakajima A, Yamanaka H, Harigai M. Trends in Risks of Malignancies in Japanese Patients with Rheumatoid Arthritis: Analyses from a 14-year Observation of the IORRA Cohort Mod Rheumatol. 2022 Aug 3:roac085. doi: 10.1093/mr/roac085. Online ahead of print.doi: 10.1093/mr/roac085 PMID35920098.0
2. Nakajima A, Sakai R, Inoue E, Harigai M. Geographic variations in rheumatoid arthritis treatment in Japan: A nationwide retrospective study using the national database of health insurance claims and specific health checkups of Japan Mod Rheumatol. 2022 Jan 5;32(1):105-113. doi: 10.1080/14397595.2021.1910615. PMID33818268
3. Takada H, Kaneko Y, Nakano K, Tanaka M, Fujii T, Saito K, Sugimoto N, Sasaki S, Saito S, Saito R, Kuramoto N, Harigai M, Suzuki Y. Clinicopathological characteristics of lymphoproliferative disorders in 232 patients with rheumatoid arthritis in Japan: A retrospective, multicenter, descriptive study Mod Rheumatol. 2022 Jan 5;32(1):32-40. doi: 10.1080/14397595.2021.1899570. PMID33705243
4. Higuchi T, Tanaka E, Inoue E, Abe M, Saka K, Sugano E, Sugitani N, Higuchi Y, Ochiai M, Yamaguchi R, Sugimoto N, Ikari K, Yamanaka H, Harigai M. Impact of concomitant chronic kidney disease on hospitalised infections and remission in patients with rheumatoid arthritis: results from the IORRA cohort Mod Rheumatol. 2022 Aug 20;32(5):875-884. doi: 10.1093/mr/roab082. PMID34751783
5. Saito R, Tanaka M, Ito H, Kuramoto N, Fujii T, Saito S, Kaneko Y, Nakano K, Saito K, Takada H, Sugimoto N, Sasaki S, Harigai M, Suzuki Y. Overall survival and post-spontaneous regression relapse-free survival of patients with lymphoproliferative disorders associated with rheumatoid arthritis: a multi-center retrospective cohort study Mod Rheumatol. 2022 Jan 5;32(1):50-58. doi: 10.1080/14397595.2020.1866837. PMID33336615
6. Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara K, Yamaguchi K, Amariuta T, Too CL, Laufer VA, Scott IC, Viatte S, Takahashi M, Ohmura K, Murasawa A, Hashimoto M, Ito H, Hammoudeh M, Emadi SA, Masri BK, Halabi H, Badsha H, Uthman IW, Wu X, Lin L, Li T, Plant D, Barton A, Orozco G, Verstappen SMM, Bowes J, MacGregor AJ, Honda S, Koido M, Tomizuka K, Kamatani Y, Tanaka H, Tanaka E, Suzuki A, Maeda Y, Yamamoto K, Miyawaki S, Xie G, Zhang J, Amos CI, Keystone E, Wolbink G, van der Horst-Bruinsma I, Cui J, Liao KP, Carroll RJ, Lee HS, Bang SY, Siminovitch KA, de Vries N, Alfredsson L, Rantapää-Dahlqvist S, Karlson EW, Bae SC, Kimberly RP, Edberg JC, Mariette X, Huizinga T, Dieudé P, Schneider M, Kerick M, Denny JC; BioBank Japan Project; Matsuda K, Matsuo K, Mimori T, Matsuda F, Fujio K, Tanaka Y, Kumanogoh A, Traylor M, Lewis CM, Eyre S, Xu H, Saxena R, Arayssi T, Kochi Y, Ikari K, Harigai M, Gregersen PK, Yamamoto K, Louis Bridges S Jr, Padyukov L, Martin J, Klareskog L, Okada Y, Raychaudhuri S. Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis Nat Genet. 2022 Nov;54(11):1640-1651. doi: 10.1038/s41588-022-01213-w. Epub 2022 Nov 4. PMID36333501
7. Honda S, Yano K, Tanaka E, Ikari K, Harigai M. Development of a scoring model for the Sharp/van der Heijde score using convolutional neural networks and its clinical application Rheumatology (Oxford). 2022 Oct 11:keac586. doi: 10.1093/rheumatology/keac586. Online ahead of print. PMID36218391
8. Tamura N, Azuma T, Misaki K, Yamaguchi R, Hirano F, Sugiyama E, Kanai D, Murakawa Y, Oribe M, Kimata T, Aoki K, Sugiura T, Takasugi K, Takakubo Y, Tomita Y, Isozaki T, Nanki T, Katsuyama N, Kuroiwa T, Oshikawa H, Kaneko M, Fujinaga H, Saito K, Tanaka E, Inoue E, Yoshizawa Y, Matsumoto S, Yamanaka H, Harigai M. Effectiveness and safety of subcutaneous abatacept in biologic-naive RA patients at Week 52: A Japanese multicentre investigational study (ORIGAMI study) Mod Rheumatol. 2022 Aug 20;32(5):846-856. doi: 10.1093/mr/roab090. PMID34915575
9. Furuya T. Clinical observations of osteoporosis in Japanese patients with rheumatoid arthritis Mod Rheumatol. 2022 Aug 20;32(5):839-845. doi: 10.1093/mr/roab130. PMID34979563
10. Okamoto Y, Demoruelle MK. Reply Arthritis Rheumatol. 2022 Jul;74(7):1299-1300. doi: 10.1002/art.42115. Epub 2022 May 18. PMID35289121
11. Ishikawa Y, Ikari K, Terao C. Response to: 'Corresponence on 'Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor' by Ishikawa et al' by Regueiro and Gonzalez Ann Rheum Dis. 2022 Jan;81(1):e2. doi: 10.1136/annrheumdis-2019-216872. Epub 2020 Feb 14. PMID32060037
12. Okamoto Y, Devoe S, Seto N, Minarchick V, Wilson T, Rothfuss HM, Mohning MP, Arbet J, Kroehl M, Visser A, August J, Thomas SM, Charry LL, Fleischer C, Feser ML, Frazer-Abel AA, Norris JM, Cherrington BD, Janssen WJ, Kaplan MJ, Deane KD, Holers VM, Demoruelle MK. Association of Sputum Neutrophil Extracellular Trap Subsets With IgA Anti-Citrullinated Protein Antibodies in Subjects at Risk for Rheumatoid Arthritis Arthritis Rheumatol. 2022 Jan;74(1):38-48. doi: 10.1002/art.41948. Epub 2021 Nov 25. PMID34369110
13. Furuya T, Oh K, Ikari K, Inoue E, Tanaka E, Yamanaka H, Harigai M. Factors associated with frailty in Japanese patients with rheumatoid arthritis: results from the Institute of Rheumatology Rheumatoid Arthritis cohort study Clin Rheumatol. 2022 Feb;41(2):405-410. doi: 10.1007/s10067-021-05938-7. Epub 2021 Sep 29. PMID34586516
14. Nakano K, Tanaka Y, Saito K, Kaneko Y, Saito S, Tanaka M, Saito R, Fujii T, Kuramoto N, Sugimoto N, Takada H, Harigai M, Sasaki S, Suzuki Y. Treatment of rheumatoid arthritis after regression of lymphoproliferative disorders in patients treated with methotrexate: a retrospective, multi-center descriptive study Mod Rheumatol. 2022 Jan 5;32(1):41-49. doi: 10.1080/14397595.2020.1847775. PMID33164614
15. Sakai R, Tanaka E, Majima M, Harigai M. Unincreased risk of hospitalized infection under targeted therapies versus methotrexate in elderly patients with rheumatoid arthritis: a retrospective cohort study Arthritis Res Ther. 2022 Jun 10;24(1):135. doi: 10.1186/s13075-022-02807-9. PMID35689250
16. Honda S, Ikari K, Yano K, Terao C, Tanaka E, Harigai M, Kochi Y. Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis Arthritis Rheumatol. 2022 May;74(5):791-800. doi: 10.1002/art.42051. Epub 2022 Mar 24. PMID35048562
17. Sakai R, Tanaka E, Inoue E, Sato M, Tanaka M, Ikari K, Yamanaka H, Harigai M. Subjective Symptoms Contributing to the Quality of Life of Rheumatoid Arthritis Patients with Clinical Remission from the IORRA Database Mod Rheumatol. 2022 Jun 2:roac053. doi: 10.1093/mr/roac053. Online ahead of print. PMID35652691
18. Honda S, Sakai R, Inoue E, Majima M, Konda N, Takada H, Kihara M, Yajima N, Nanki T, Yamamoto K, Takeuchi T, Harigai M. Association of methotrexate use and lymphoproliferative disorder in patients with rheumatoid arthritis: Results from a Japanese multi-institutional retrospective study Mod Rheumatol. 2022 Jan 5;32(1):16-23. doi: 10.1080/14397595.2020.1869370. PMID33428479
19. Harigai M, Tsuritani K, Yoshizawa Y, Atsumi T, Tanaka Y. Long-term safety and effectiveness of abatacept in Japanese patients with rheumatoid arthritis: 3-year follow-up of a postmarketing surveillance Mod Rheumatol. 2022 Apr 18;32(3):508-516. doi: 10.1093/mr/roab050. PMID34910191
20. Sugano E, Tanaka E, Inoue E, Sakai R, Abe M, Saka K, Sugitani N, Ochiai M, Yamaguchi R, Higuchi Y, Sugimoto N, Ikari K, Nakajima A, Yamanaka H, Harigai M. Differences in patients' population and efficacy/effectiveness of biologic disease-modifying antirheumatic drugs between randomized controlled trials and real-world settings in patients with rheumatoid arthritis - using the IORRA cohort Mod Rheumatol. 2022 Jul 1;32(4):675-685. doi: 10.1093/mr/roab067. PMID34918127
21. Tominaga A, Ikari K, Yano K, Tanaka E, Inoue E, Harigai M, Okazaki K. Surgical Intervention for Patients With Rheumatoid Arthritis is Declining Except for Foot and Ankle Surgery: A Single-Center, 20-Year Observational Cohort Study Mod Rheumatol. 2022 May 10:roac042. doi: 10.1093/mr/roac042. Online ahead of print. PMID35536604
22. Hirose W, Harigai M, Amano K, Hidaka T, Itoh K, Aoki K, Nakashima M, Nagasawa H, Komano Y, Nanki T. Real-world effectiveness and safety of tofacitinib and abatacept in patients with rheumatoid arthritis Rheumatol Adv Pract. 2022 Oct 29;6(3):rkac090. doi: 10.1093/rap/rkac090. eCollection 2022. PMID36407801
23. Sakai R, Tanaka E, Inoue E, Sato M, Tanaka M, Ikari K, Yamanaka H, Harigai M. Association between patient-reported outcomes and impairments in work and activity in patients with rheumatoid arthritis in clinical remission: a retrospective analysis using the IORRA database Mod Rheumatol. 2022 Sep 12:roac105. doi: 10.1093/mr/roac105. Online ahead of print. PMID36094815
24. Sobue Y, Kojima M, Kojima T, Ito H, Nishida K, Matsushita I, Hirata S, Kaneko Y, Kishimoto M, Kohno M, Murashima A, Morinobu A, Mori M, Nakayama T, Sugihara T, Seto Y, Tanaka E, Hasegawa M, Kawahito Y, Harigai M. Patient satisfaction with total joint replacement surgery for rheumatoid arthritis: a questionnaire survey for the 2020 update of the Japan college of rheumatology clinical practice guidelines Mod Rheumatol. 2022 Jan 5;32(1):121-126. doi: 10.1080/14397595.2021.1892258. PMID33617382
25. Ito H, Murata K, Sobue Y, Kojima T, Nishida K, Matsushita I, Kawahito Y, Kojima M, Hirata S, Kaneko Y, Kishimoto M, Kohno M, Mori M, Morinobu A, Murashima A, Seto Y, Sugihara T, Tanaka E, Nakayama T, Harigai M. Comprehensive risk analysis of postoperative complications in patients with rheumatoid arthritis for the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis Mod Rheumatol. 2022 Feb 28;32(2):296-306. doi: 10.1080/14397595.2021.1913824. PMID33855932
26. Tanaka E, Inoue E, Abe M, Saka K, Sugano E, Ochiai M, Yamaguchi R, Ikari K, Yamanaka H, Harigai M. Changes in treatment adherence and behaviour during the COVID-19 pandemic in Japanese patients with rheumatoid arthritis: Results from cross-sectional study in the IORRA cohort Mod Rheumatol. 2022 Oct 15;32(6):1193-1195. doi: 10.1093/mr/roab120. PMID35445721
27. Azuma T, Misaki K, Kusaoi M, Suzuki Y, Higa S, Kumon Y, Yoshitama T, Naniwa T, Yamada S, Okano T, Takeuchi K, Ikeda K, Higami K, Inoo M, Sawada T, Kang C, Hayashi M, Nagaya Y, Hagiwara T, Shono E, Himeno S, Tanaka E, Inoue E, Yoshizawa Y, Kadode M, Yamanaka H, Harigai M. Influence of Concomitant Methotrexate use on the Clinical Effectiveness, Retention, and Safety of Abatacept in Biologic-Naïve Patients with Rheumatoid Arthritis: Post-hoc Subgroup Analysis of ORIGAMI Study Mod Rheumatol. 2022 Apr 7:roac032. doi: 10.1093/mr/roac032. Online ahead of print. PMID35389481
28. Kojima M, Hasegawa M, Hirata S, Ito H, Kaneko Y, Kishimoto M, Kohno M, Kojima T, Matsushita I, Mori M, Morinobu A, Murashima A, Nishida K, Seto Y, Sobue Y, Sugihara T, Tanaka E, Nakayama T, Kawahito Y, Harigai M. Patients' perspectives of rheumatoid arthritis treatment: a questionnaire survey for the 2020 update of the Japan college of rheumatology clinical practice guidelines Mod Rheumatol. 2022 Feb 28;32(2):307-312. doi: 10.1080/14397595.2021.1913276. PMID33853492
29. Tanaka E, Kawahito Y, Kohno M, Hirata S, Kishimoto M, Kaneko Y, Tamai H, Seto Y, Morinobu A, Sugihara T, Murashima A, Kojima M, Mori M, Ito H, Kojima T, Sobue Y, Nishida K, Matsushita I, Nakayama T, Yamanaka H, Harigai M. Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis Mod Rheumatol. 2022 Jan 5;32(1):74-86. doi: 10.1080/14397595.2021.1899591. PMID33706664
30. Tanaka E, Inoue E, Shoji A, Nilsson J, Papagiannopoulos C, Dhanda D, Yoshizawa Y, Abe M, Saka K, Sugano E, Sugitani N, Ochiai M, Yamaguchi R, Ikari K, Yamanaka H, Harigai M. Cost-consequence of abatacept as first-line therapy in Japanese rheumatoid arthritis patients using IORRA real-world data PLoS One. 2022 Nov 16;17(11):e0277566. doi: 10.1371/journal.pone.0277566. eCollection 2022. PMID36383610
31. Sobue Y, Kojima T, Ito H, Nishida K, Matsushita I, Kaneko Y, Kishimoto M, Kohno M, Sugihara T, Seto Y, Tanaka E, Nakayama T, Hirata S, Murashima A, Morinobu A, Mori M, Kojima M, Kawahito Y, Harigai M. Does exercise therapy improve patient-reported outcomes in rheumatoid arthritis? A systematic review and meta-analysis for the update of the 2020 JCR guidelines for the management of rheumatoid arthritis Mod Rheumatol. 2022 Jan 5;32(1):96-104. doi: 10.1080/14397595.2021.1886653. PMID33565350
32. Kuramoto N, Saito S, Fujii T, Kaneko Y, Saito R, Tanaka M, Takada H, Nakano K, Saito K, Sugimoto N, Sasaki S, Harigai M, Suzuki Y. Characteristics of rheumatoid arthritis with immunodeficiency-associated lymphoproliferative disorders to regress spontaneously by the withdrawal of methotrexate and their clinical course: A retrospective, multicenter, case-control study Mod Rheumatol. 2022 Jan 5;32(1):24-31. doi: 10.1080/14397595.2021.1879362. PMID33496194
33. Sugihara T, Kawahito Y, Morinobu A, Kaneko Y, Seto Y, Kojima T, Ito H, Kohno M, Nakayama T, Sobue Y, Nishida K, Matsushita I, Murashima A, Mori M, Tanaka E, Hirata S, Kishimoto M, Yamanaka H, Kojima M, Harigai M. Systematic review for the treatment of older rheumatoid arthritis patients informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis Mod Rheumatol. 2022 Feb 28;32(2):313-322. doi: 10.1080/14397595.2021.1912922. PMID33853484
34. Yamaguchi R, Tanaka E, Nakajima A, Inoue E, Abe M, Sugano E, Sugitani N, Saka K, Ochiai M, Higuchi Y, Sugimoto N, Ikari K, Yamanaka H, Harigai M. Risk of herpes zoster in patients with rheumatoid arthritis in the biologics era from 2011 to 2015 and its association with methotrexate, biologics, and corticosteroids Mod Rheumatol. 2022 Apr 18;32(3):522-527. doi: 10.1093/mr/roab026. PMID34897494
35. Kojima M, Kawahito Y, Sugihara T, Kojima T, Harada R, Hirata S, Hashimoto M, Hidaka T, Ishikawa H, Ito H, Kishimoto M, Kaneko Y, Matsui K, Matsui T, Matsushita I, Morinobu A, Nishida K, Tanaka E, Abe A, Ishitoku M, Asai S, Kida T, Onishi A, Takanashi S, Harigai M. Late-onset rheumatoid arthritis registry study, LORIS study: study protocol and design BMC Rheumatol. 2022 Dec 26;6(1):90. doi: 10.1186/s41927-022-00322-7. PMID36567352
リウマチ整形
1. Mochizuki T, Yano K, Ikari K, Okazaki K. Effects of the COVID-19 pandemic on body composition among patients with rheumatoid arthritis Mod Rheumatol. 2022 Feb 28;32(2):452-454. doi: 10.1093/mr/roab018. PMID34894260
2. Mochizuki T, Yano K, Ikari K, Okazaki K. Cut-off values for achieving osteoporosis treatment goals in women with rheumatoid arthritis receiving denosumab Mod Rheumatol. 2022 Dec 9:roac145. doi: 10.1093/mr/roac145. Online ahead of print. PMID36484528
3. Yano K, Tobimatsu H, Ikari K, Okazaki K. How reliable is assessment of joint swelling and tenderness over socks or stockings in patients with established rheumatoid arthritis? Mod Rheumatol. 2022 Oct 15;32(6):1023-1026. doi: 10.1093/mr/roab101. PMID34891174
4. Mochizuki T, Kurata A, Yano K, Ikari K, Okazaki K. Effects of Locomotion Training on the Physical Functions and Quality of Life in Patients with Rheumatoid Arthritis: A Pilot Clinical Trial Prog Rehabil Med. 2022 Mar 29;7:20220014. doi: 10.2490/prm.20220014. eCollection 2022. PMID35434407
5. Mochizuki T, Yano K, Ikari K, Okazaki K. Factors Associated with Five-year Deterioration of the Health Assessment Questionnaire-Disability Index in Patients with Rheumatoid Arthritis: A Retrospective Cohort Study Intern Med. 2022 Nov 2. doi: 10.2169/internalmedicine.0651-22. Online ahead of print. PMID36328576
6. Mochizuki T, Yano K, Ikari K, Hiroshima R, Okazaki K. Comparison of Romosozumab Versus Denosumab Treatment on Bone Mineral Density After One Year in Rheumatoid Arthritis Patients with Severe Osteoporosis: A Randomized Clinical Pilot Study Mod Rheumatol. 2022 Jun 11:roac059. doi: 10.1093/mr/roac059. Online ahead of print. PMID35689558
7. Mikashima Y, Imamura H, Shirakawa Y, Yano K, Ikari K, Okazaki K. Modern cementless posterior stabilized mobile-bearing total knee arthroplasty shows comparable clinical and radiographical results to its cemented predecessor at 1-year follow-up Knee Surg Sports Traumatol Arthrosc. 2022 Sep;30(9):3131-3137. doi: 10.1007/s00167-022-07047-7. Epub 2022 Jul 4. PMID35781580
8. Yano K, Ikari K. Outcomes of Joint-Preserving Surgery for Rheumatoid Forefoot Deformity: An Editorial Int J Environ Res Public Health. 2022 Feb 11;19(4):2038. doi: 10.3390/ijerph19042038. PMID35206226
9. Mochizuki T, Hori T, Yano K, Ikari K, Okazaki K. Changes in SARS-CoV-2 Antibody Titers from Three to Nine Months after Administration of the BNT162b2 mRNA Vaccine among Healthcare Workers in Japan: A Prospective Study Intern Med. 2022 Jul 1;61(13):2095. doi: 10.2169/internalmedicine.9695-22. Epub 2022 Apr 23. PMID35466173
10. Mochizuki T, Yano K, Ikari K, Okazaki K. Two-year effectiveness of zoledronic acid with or without eldecalcitol in Japanese patients with osteoporosis: A randomized prospective study Osteoporos Sarcopenia. 2022 Jun;8(2):75-79. doi: 10.1016/j.afos.2022.05.001. Epub 2022 May 20. PMID35832418
11. Mochizuki T, Hori T, Yano K, Ikari K, Okazaki K. Factors Associated with Change in SARS-CoV-2 Antibody Titers from Three to Six Months after the Administration of the BNT162b2 mRNA COVID-19 Vaccine among Healthcare Workers in Japan: A Prospective Study Intern Med. 2022 Apr 15;61(8):1139-1143. doi: 10.2169/internalmedicine.8902-21. Epub 2022 Feb 19. PMID35185050
12. Mochizuki T, Nasu Y, Yano K, Ikari K, Hiroshima R, Okazaki K. Foot and ankle functions and deformities focus on posterior tibial tendon dysfunction using magnetic resonance imaging in patients with rheumatoid arthritis Mod Rheumatol. 2022 Aug 20;32(5):885-890. doi: 10.1093/mr/roab084. PMID34918140
SLE
1. Yamashita S, Katsumata Y, Konda N, Kandane-Rathnayake R, Morand EF, Harigai M. Comparisons Between US Norm-based Two-component and Japanese Norm-based Three-component SF-36 Summary Scores in Systemic Lupus Erythematosus Patients Mod Rheumatol. 2022 Jun 11:roac061. doi: 10.1093/mr/roac061. Online ahead of print. PMID35689562
SF-36は、健康関連QoLの評価法であり、SLE を含む多くの疾患で使用されています。オリジナル英語版では8つ
2. Kandane-Rathnayake R, Louthrenoo W, Luo SF, Wu YJ, Chen YH, Golder V, Lateef A, Cho J, Navarra SV, Zamora L, Hamijoyo L, Sockalingam S, An Y, Li Z, Montes R, Oon S, Katsumata Y, Harigai M, Hao Y, Zhang Z, Chan M, Kikuchi J, Takeuchi T, Goldblatt F, O'Neill S, Bae SC, Lau CS, Hoi A, Karyekar CS, Nikpour M, Morand EF; Asia-Pacific Lupus Collaboration. Patterns of Medication Use in Systemic Lupus Erythematosus: A Multicenter Cohort Study Arthritis Care Res (Hoboken). 2022 Dec;74(12):2033-2041. doi: 10.1002/acr.24740. Epub 2022 Aug 22. PMID34197023
3. Suetsugu H, Kim K, Yamamoto T, Bang SY, Sakamoto Y, Shin JM, Sugano N, Kim JS, Mukai M, Lee YK, Ohmura K, Park DJ, Takahashi D, Ahn GY, Karino K, Kwon YC, Miyamura T, Kim J, Nakamura J, Motomura G, Kuroda T, Niiro H, Miyamoto T, Takeuchi T, Ikari K, Amano K, Tada Y, Yamaji K, Shimizu M, Atsumi T, Seki T, Tanaka Y, Kubo T, Hisada R, Yoshioka T, Yamazaki M, Kabata T, Kajino T, Ohta Y, Okawa T, Naito Y, Kaneuji A, Yasunaga Y, Ohzono K, Tomizuka K, Koido M, Matsuda K, Okada Y, Suzuki A, Kim BJ, Kochi Y, Lee HS, Ikegawa S, Bae SC, Terao C. Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus Hum Mol Genet. 2022 Mar 31;31(7):1082-1095. doi: 10.1093/hmg/ddab306. PMID34850884
4. Connelly K, Kandane-Rathnayake R, Hoi A, Louthrenoo W, Hamijoyo L, Cho J, Lateef A, Luo SF, Wu YJ, Li ZG, Navarra S, Zamora L, Sockalingam S, Hao Y, Zhang Z, Katsumata Y, Harigai M, Oon S, Chan M, Chen Y, Bae SC, O'Neill S, Goldblatt F, Kikuchi J, Takeuchi T, Ng K, Tugnet N, Basnayake BMDB, Ohkubo N, Tanaka Y, Lau CS, Golder V, Nikpour M, Morand E Associations of improvement in laboratory tests with clinical outcomes in patients with active systemic lupus erythematosus Lancet Rheumatol. 2022;4(12):e831-841. PMIDnan
5. Kandane-Rathnayake R, Louthrenoo W, Hoi A, Luo SF, Wu YJ, Chen YH, Cho J, Lateef A, Hamijoyo L, Navarra SV, Zamora L, Sockalingam S, An Y, Li Z, Katsumata Y, Harigai M, Hao Y, Zhang Z, Kikuchi J, Takeuchi T, Basnayake BMDB, Chan M, Ng KPL, Tugnet N, Kumar S, Oon S, Goldblatt F, O'Neill S, Gibson KA, Ohkubo N, Tanaka Y, Bae SC, Lau CS, Nikpour M, Golder V, Morand EF; Asia-Pacific Lupus Collaboration. 'Not at target': prevalence and consequences of inadequate disease control in systemic lupus erythematosus-a multinational observational cohort study Arthritis Res Ther. 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. PMID35287720
6. Connelly K, Kandane-Rathnayake R, Hoi A, Louthrenoo W, Hamijoyo L, Luo SF, Wu YJ, Cho J, Lateef A, Lau CS, Chen YH, Navarra S, Zamora L, Li Z, An Y, Sockalingam S, Hao Y, Zhang Z, Chan M, Katsumata Y, Harigai M, Oon S, Bae SC, O'Neill S, Gibson KA, Basnayake B, Kikuchi J, Takeuchi T, Ng KPL, Tugnet N, Kumar S, Goldblatt F, Law A, Tee M, Tee C, Tanaka Y, Ohkubo N, Tan JY, Karyekar CS, Nikpour M, Golder V, Morand EF. Association of Modified Systemic Lupus Erythematosus Responder Index Attainment With Long-Term Clinical Outcomes: A Five-Year Prospective Study Arthritis Rheumatol. 2022 Sep 19. doi: 10.1002/art.42350. Online ahead of print. PMID36122172
7. Yin X, Kim K, Suetsugu H, Bang SY, Wen L, Koido M, Ha E, Liu L, Sakamoto Y, Jo S, Leng RX, Otomo N, Kwon YC, Sheng Y, Sugano N, Hwang MY, Li W, Mukai M, Yoon K, Cai M, Ishigaki K, Chung WT, Huang H, Takahashi D, Lee SS, Wang M, Karino K, Shim SC, Zheng X, Miyamura T, Kang YM, Ye D, Nakamura J, Suh CH, Tang Y, Motomura G, Park YB, Ding H, Kuroda T, Choe JY, Li C, Niiro H, Park Y, Shen C, Miyamoto T, Ahn GY, Fei W, Takeuchi T, Shin JM, Li K, Kawaguchi Y, Lee YK, Wang YF, Amano K, Park DJ, Yang W, Tada Y, Lau YL, Yamaji K, Zhu Z, Shimizu M, Atsumi T, Suzuki A, Sumida T, Okada Y, Matsuda K, Matsuo K, Kochi Y; Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head; Yamamoto K, Ohmura K, Kim TH, Yang S, Yamamoto T, Kim BJ, Shen N, Ikegawa S, Lee HS, Zhang X, Terao C, Cui Y, Bae SC. Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study Ann Rheum Dis. 2022 May 24;81(9):1273-80. doi: 10.1136/annrheumdis-2022-222345. Online ahead of print. PMID35609976
全身性強皮症
1. Lescoat A, Huscher D, Schoof N, Airò P, de Vries-Bouwstra J, Riemekasten G, Hachulla E, Doria A, Rosato E, Hunzelmann N, Montecucco C, Gabrielli A, Hoffmann-Vold AM, Distler O, Ben Shimol J, Cutolo M, Allanore Y; EUSTAR collaborators. Systemic sclerosis-associated interstitial lung disease in the EUSTAR database: analysis by region Rheumatology (Oxford). 2022 Oct 12:keac576. doi: 10.1093/rheumatology/keac576. Online ahead of print. PMID36222557
皮膚筋炎/多発筋炎
1. Ichimura Y, Konishi R, Shobo M, Inoue S, Okune M, Maeda A, Tanaka R, Kubota N, Matsumoto I, Ishii A, Tamaoka A, Shimbo A, Mori M, Morio T, Kishi T, Miyamae T, Tanboon J, Inoue M, Nishino I, Fujimoto M, Nomura T, Okiyama N. Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash Rheumatology (Oxford). 2022 Mar 2;61(3):1222-1227. doi: 10.1093/rheumatology/keab518. PMID34152410
2. Ichimura Y, Konishi R, Shobo M, Inoue S, Okune M, Maeda A, Tanaka R, Kubota N, Matsumoto I, Ishii A, Tamaoka A, Shimbo A, Mori M, Morio T, Kishi T, Miyamae T, Tanboon J, Inoue M, Nishino I, Fujimoto M, Nomura T, Okiyama N. Reliability of antinuclear matrix protein 2 antibody assays in idiopathic inflammatory myopathies is dependent on target protein properties J Dermatol. 2022 Apr;49(4):441-447. doi: 10.1111/1346-8138.16295. Epub 2021 Dec 29. PMID34967032
3. Kimura N, Kawahara T, Uemura Y, Atsumi T, Sumida T, Mimura T, Kawaguchi Y, Amano H, Iwasaki Y, Kaneko Y, Matsui T, Muro Y, Imura Y, Kanda T, Tanaka Y, Kawakami A, Jinnin M, Ishii T, Hiromura K, Miwa Y, Nakajima H, Kuwana M, Nishioka Y, Morinobu A, Kameda H, Kohsaka H. Branched chain amino acids in the treatment of polymyositis and dermatomyositis: a phase II/III, multi-centre, randomized controlled trial Rheumatology (Oxford). 2022 Nov 2;61(11):4445-4454. doi: 10.1093/rheumatology/keac101. PMID35179548
血管炎
1. Watanabe R, Oshima M, Nishioka N, Sada KE, Nagasaka K, Akiyama M, Ando T, Higuchi T, Inoue Y, Kida T, Mutoh T, Nakabayashi A, Onishi A, Sakai R, Waki D, Yamada Y, Yajima N, Tamura N, Kaname S, Harigai M. Systematic review and meta-analysis for 2023 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis Mod Rheumatol. 2022 Sep 16:roac114. doi: 10.1093/mr/roac114. Online ahead of print. PMID36112482
ANCA関連血管炎診療ガイドライン改訂のためのシステマティックレビューに関する論文を難治性血管炎班で作成しました。現時点における最新のエビデンスをまとめた非常に有用な論文です。
2. Bando M, Homma S, Harigai M. MPO-ANCA positive interstitial pneumonia: Current knowledge and future perspectives Sarcoidosis Vasc Diffuse Lung Dis. 2022;38(4):e2021045. doi: 10.36141/svdld.v38i4.11808. Epub 2022 Jan 13. PMID35115752
3. Danda D, Manikuppam P, Tian X, Harigai M. Advances in Takayasu arteritis: An Asia Pacific perspective Front Med (Lausanne). 2022 Aug 15;9:952972. doi: 10.3389/fmed.2022.952972. eCollection 2022. PMID36045929
4. Nakaya I, Sada KE, Harigai M, Soma J, Amano K, Dobashi H, Atsumi T, Yuzawa Y, Fujimoto S, Sugihara T, Takasaki Y, Arimura Y, Makino H. Chemoprophylaxis against Pneumocystis jirovecii pneumonia in Japanese patients with ANCA-associated vasculitis: an observational study Mod Rheumatol. 2022 Oct 5:roac124. doi: 10.1093/mr/roac124. Online ahead of print. PMID36197746
5. Yoshinari M, Nishibata Y, Masuda S, Nakazawa D, Tomaru U, Arimura Y, Amano K, Yuzawa Y, Sada KE, Atsumi T, Dobashi H, Hasegawa H, Harigai M, Matsuo S, Makino H, Ishizu A. Low disease activity of microscopic polyangiitis in patients with anti-myosin light chain 6 antibody that disrupts actin rearrangement necessary for neutrophil extracellular trap formation Arthritis Res Ther. 2022 Dec 16;24(1):274. doi: 10.1186/s13075-022-02974-9. PMID36527167
6. Arimura Y, Sobue G, Hattori N, Takashima H, Harigai M, Nagata K, Makino H. Intravenous immunoglobulin for chronic residual peripheral neuropathy in microscopic polyangiitis: A multicentre randomised double-blind trial Mod Rheumatol. 2022 Nov 8:roac137. doi: 10.1093/mr/roac137. Online ahead of print. PMID36346309
7. Harigai M, Miyamae T, Hashimoto H, Yoshida A, Yamashita K, Nakaoka Y. A Multicentre, Large-Scale, Observational Study of Tocilizumab in Patients with Takayasu Arteritis in Japan: The ACT-Bridge Study Mod Rheumatol. 2022 Sep 3:roac099. doi: 10.1093/mr/roac099. Online ahead of print. PMID36057089
8. Sugihara T, Nakaoka Y, Uchida HA, Yoshifuji H, Maejima Y, Watanabe Y, Amiya E, Tanemoto K, Miyata T, Umezawa N, Manabe Y, Ishizaki J, Shirai T, Nagafuchi H, Hasegawa H, Miyamae T, Niiro H, Ito S, Ishii T, Isobe M, Harigai M. Establishing clinical remission criteria and the framework of a treat-to-target algorithm for Takayasu arteritis: Results of a Delphi exercise carried out by an expert panel of the Japan Research Committee of the Ministry of Health, Labour and Welfare for intractable vasculitis Mod Rheumatol. 2022 Aug 20;32(5):930-937. doi: 10.1093/mr/roab081. PMID34850081
9. Harigai M, Takada H. Avacopan, a selective C5a receptor antagonist, for anti-neutrophil cytoplasmic antibody-associated vasculitis Mod Rheumatol. 2022 Apr 18;32(3):475-483. doi: 10.1093/mr/roab104. PMID34984461
10. Nagasaka K, Amano K, Dobashi H, Nagafuchi H, Sada KE, Komagata Y, Yamamura M, Kato M, Endo T, Nakaya I, Takeuchi T, Murakawa Y, Sugihara T, Saito M, Hayashi T, Furuta S, Tamura N, Karasawa K, Banno S, Endo S, Majima M, Kaname S, Arimura Y, Harigai M. Nation-wide Cohort Study of Remission Induction Therapy using Rituximab in Japanese patients with ANCA-Associated Vasculitis: effectiveness and safety in the first six months Mod Rheumatol. 2022 Dec 8:roac150. doi: 10.1093/mr/roac150. Online ahead of print. PMID36478050
11. Harigai M, Kaname S, Tamura N, Dobashi H, Kubono S, Yoshida T. Efficacy and Safety of Avacopan in Japanese Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Subanalysis of a Randomized Phase 3 Study Mod Rheumatol. 2022 Apr 28:roac037. doi: 10.1093/mr/roac037. Online ahead of print. PMID35482532
12. Sugihara T, Uchida HA, Yoshifuji H, Maejima Y, Naniwa T, Katsumata Y, Okazaki T, Ishizaki J, Murakawa Y, Ogawa N, Dobashi H, Horita T, Tanaka Y, Furuta S, Takeuchi T, Komagata Y, Nakaoka Y, Harigai M. Association between the patterns of large-vessel lesions and treatment outcomes in patients with large-vessel giant cell arteritis Mod Rheumatol. 2022 Oct 11:roac122. doi: 10.1093/mr/roac122. Online ahead of print. PMID36218378
13. Nagasaka K, Kaname S, Amano K, Kato M, Katsumata Y, Komagata Y, Sada KE, Tanaka E, Tamura N, Dobashi H, Nanki T, Harabuchi Y, Bando M, Homma S, Wada T, Harigai M. Nation-wide survey of the treatment trend of microscopic polyangiitis and granulomatosis with polyangiitis in Japan using the Japanese Ministry of Health, Labour and Welfare Database Mod Rheumatol. 2022 Aug 20;32(5):915-922. doi: 10.1093/mr/roab088. PMID34918136
14. Kawazoe M, Nanki T, Hagino N, Ikegaya N, Ito S, Kodera M, Nakano N, Suzuki M, Kaname S, Harigai M. Clinical characteristics of patients with polyarteritis nodosa based on a nationwide database in Japan Mod Rheumatol. 2022 Apr 18;32(3):598-605. doi: 10.1093/mr/roab019. PMID34894268
15. Miyawaki Y, Fujii T, Anan K, Kodera M, Kikuchi M, Sada KE, Nagasaka K, Bando M, Sugiyama H, Kaname S, Harigai M, Tamura N. Concordance between practice and published evidence in the management of ANCA-associated vasculitis in Japan: a cross-sectional web-questionnaire survey Mod Rheumatol. 2022 Oct 1:roac118. doi: 10.1093/mr/roac118. Online ahead of print. PMID36181464
小児リウマチ科
1. Miyamae T, Bando Y. Transition of Patients with Childhood-onset Rheumatic Diseases to Adult Medical Care in Japan Intern Med. 2022 Oct 19. doi: 10.2169/internalmedicine.0859-22. Online ahead of print. PMID36261384
2. Mori M, Akioka S, Igarashi T, Inoue Y, Umebayashi H, Ohshima S, Nishiyama S, Hashimoto M, Matsui T, Miyamae T, Yasumi T. Transitioning from paediatric to adult rheumatological healthcare: English summary of the Japanese Transition Support Guide Mod Rheumatol. 2022 Feb 28;32(2):248-255. doi: 10.1093/mr/roab071. PMID34918115
3. Narazaki H, Akioka S, Akutsu Y, Araki M, Fujieda M, Fukuhara D, Hara R, Hashimoto K, Hattori S, Hayashibe R, Imagawa T, Inoue Y, Ishida H, Ito S, Itoh Y, Kawabe T, Kitoh T, Kobayashi I, Matsubayashi T, Miyamae T, Mizuta M, Mori M, Murase A, Nakagishi Y, Nagatani K, Nakano N, Nishimura T, Nozawa T, Okamoto N, Okura Y, Sawada H, Sawanobori E, Sugita Y, Tanabe Y, Tomiita M, Yamaguchi KI, Yasuoka R, Yokoyama K. Epidemiology conduction of paediatric rheumatic diseases based on the registry database of the Pediatric Rheumatology Association of Japan Mod Rheumatol. 2022 Sep 16:roac112. doi: 10.1093/mr/roac112. Online ahead of print. PMID36112493
4. Inoue Y, Umebayashi H, Matsui T, Nishiyama S, Sakurai I, Maru M, Takeda T, Tanigawa K, Miyamae T. Social independence evaluation index for Japanese patients with childhood-onset chronic diseases Front Pediatr. 2022 Dec 6;10:923497. doi: 10.3389/fped.2022.923497. eCollection 2022. PMID36561489
5. Sakurai I, Maru M, Miyamae T, Honda M. Prevalence and barriers to health care transition for adolescent patients with childhood-onset chronic diseases across Japan: A nation-wide cross-sectional survey Front Pediatr. 2022 Sep 1;10:956227. doi: 10.3389/fped.2022.956227. eCollection 2022. PMID36120652
6. Sherman MA, Graf R, Sabbagh SE, Galindo-Feria AS, Pinal-Fernandez I, Pak K, Kishi T, Flegel WA, Targoff IN, Miller FW, Lundberg IE, Rider LG, Mammen AL; Childhood Myositis Heterogeneity Collaborative Study Group. Anti-FHL1 autoantibodies in juvenile myositis are associated with anti-Ro52 autoantibodies but not with severe disease features Rheumatology (Oxford). 2022 Aug 12:keac428. doi: 10.1093/rheumatology/keac428. Online ahead of print. PMID35961028
7. Kishi T, Sakai R, Tani Y, Nagata S, Katsumata Y, Miyamae T, Harigai M. Trends in actual medication use for child-onset systemic lupus erythematosus using the Japanese health insurance database 2009-18 Mod Rheumatol. 2022 Apr 18;32(3):565-570. doi: 10.1093/mr/roab038. PMID34908147
8. Miyamae T, Inoue E, Tanaka E, Kawabe T, Ikari K, Harigai M. Association of Disease Activity Using SDAI and DAS-28, but not JADAS-27, with Subsequent Changes in Physical Function in Adult Patients with Juvenile Idiopathic Arthritis Mod Rheumatol. 2022 Jun 17:roac063. doi: 10.1093/mr/roac063. Online ahead of print. PMID35713223
9. Miyamae T, Inoue Y, Yamaguchi K. Checklist for rapid assessment of independence in children with pediatric rheumatic diseases in transition to adult medical care Mod Rheumatol. 2022 Feb 28;32(2):427-431. doi: 10.1080/14397595.2021.1918858. PMID33890539
その他
1. Bieber T, Feist E, Irvine AD, Harigai M, Haladyj E, Ball S, Deberdt W, Issa M, Grond S, Taylor PC. A Review of Safety Outcomes from Clinical Trials of Baricitinib in Rheumatology, Dermatology and COVID-19 Adv Ther. 2022 Nov;39(11):4910-4960. doi: 10.1007/s12325-022-02281-4. Epub 2022 Sep 5. PMID36063279