IORRA研究は、日本で初めてリウマチ性疾患領域で開始された関節リウマチの前向き大規模コホート研究です。IORRAは東京女子医科大学膠原病リウマチ痛風センター (Institute of Rheumatology) の名前からInstitute of Rheumatology, Rheumatoid Arthritisの頭文字をとりIORRAと名付けられています。
私たちは関節リウマチの観察研究であるIORRA研究を通して、様々な日常診療に根ざした、日常診療に役立つ情報を発信しています。2000年に始まったIORRA研究ですが、これまでに100を超す英文論文を発表してきました。
関節リウマチはいまだ原因不明の慢性炎症性疾患で、多関節の痛みやこわばり、炎症疾患としての発熱や体重減少、進行すると身体機能障害もきたす難治性疾患です。近年、病態の解明が進み、病態に則した治療薬が開発されることにより、関節リウマチの予後は格段に改善されてきました。多くのこのような革新的な薬剤は二重盲検試験という臨床研究を経て世の中に登場してきますが、実際の日々の臨床においては、二重盲検試験に入れないような様々な合併症に悩まされた安全性の低い患者さん達に治療を行っていかなくてはなりません。このような治療現状がどのようであるのか、それに対しどのような対応が可能であるのかなど、IORRA研究を通して示してきました。その結果、日常診療においては観察研究が必要なことが広く認識されるようになり、その考えは生物学的製剤の市販後全例調査の実施に引き継がれています。
IORRA研究の大きな柱
IORRA研究の大きな柱は現在、
1. 臨床疫学的研究
2. 薬剤経済学的研究
3. 遺伝疫学的研究
の3つです。これらは全く別なプロジェクトではなく、IORRA研究に携わる医師は共通して行っております。当センターでは、研究の縦割りはなく、研究医師の希望に応じて行われます。詳しくは女子医大学外コミュニケーション雑誌Sincere No3をご覧ください。
IORRAが成し遂げたものとこれから
RA診療の発展に貢献した
ー臨床研究の重要性が認識され、IORRAにつづいて多くのコホートができた。
ー観察研究の重要性の理解が広まった。
ー日本のRA診療レベルの高さを海外に知らしめることができた。
研究のあり方の一つの形を確立した
ー臨床が研究、教育に直結することを示すことができた。
ー個々の医師が共通のデータベース作成にかかわることにより、自身に合った臨床研究のテーマを見出し、発表することが可能となった。
ー患者主体のデータ集計が有用であることが認識された。
ー「三方良し＝患者さん良し、医師良し、製薬企業良し」の実践。
さらにその先へ
ーぶれることなく継続することが必要なこと
ーシステム構築が極めて重要であること
ーその他いろいろ
IORRA研究は、その発案者であり実行者である山中寿先生の信念が医局全体に浸透し、2000年の発足時以来変わらぬ信念で続けられています。これからも確実な臨床資料を発信し続けるIORRA研究、研修医の皆様、是非東京女子医科大学膠原病リウマチ痛風センターにいらして、一緒にIORRA研究を行いませんか。
IORRA研究業績集
英語論文
2003年
1. Matsuda Y, Singh G, Yamanaka H, Tanaka E, Urano W, Taniguchi A, Saito T, Hara M, Tomatsu T, Kamatani N. Validation of a Japanese version of the Stanford Health Assessment Questionnaire in 3,763 patients with rheumatoid arthritis. Arthritis Rheum 2003;49(6):784-8. PubMed PMID: 14673964.
2005年
2. Tanaka E, Singh G, Saito A, Syouji A, Yamada T, Urano W, Nakajima A, Taniguchi A, Tomatsu T, Hara M, Saito T, Kamatani N, Yamanaka H. Prevalence of Helicobacter pylori infection and risk of upper gastrointestinal ulcer in patients with rheumatoid arthritis in Japan. Mod Rheumatol 2005;15(5):340-5. PubMed PMID: 17029090.
3. Tanaka E, Saito A, Kamitsuji S, Yamada T, Nakajima A, Taniguchi A, Hara M, Tomatsu T, Yamanaka H, Kamatani N. Impact of shoulder, elbow, and knee joint involvement on assessment of rheumatoid arthritis using the American College of Rheumatology Core Data Set. Arthritis Rheum 2005;53(6):864-71. PubMed PMID: 16342105.
4. Kuwahara M, Ikari K, Momohara S, Nakamura T, Hara M, Yamanaka H, Tomatsu T, Kamatani N. Failure to confirm association between SLC22A4 polymorphism and rheumatoid arthritis in a Japanese population. Arthritis Rheum 2005;52(9):2947-8. PubMed PMID: 16142713.
5. Ikari K, Kuwahara M, Nakamura T, Momohara S, Hara M, Yamanaka H, Tomatsu T, Kamatani N. Association between PADI4 and rheumatoid arthritis: a replication study. Arthritis Rheum 2005;52(10):3054-7. PubMed PMID: 16200584.
2006年
6. Yamanaka H, Tohma S. Potential impact of observational cohort studies in Japan on rheumatoid arthritis research and practice. Mod Rheumatol 2006;16(2):75-6. PubMed PMID: 16633925.
7. Nakajima A, Kamitsuji S, Saito A, Tanaka E, Nishimura K, Horikawa N, Ozaki N, Tomatsu T, Hara M, Kamatani N, Yamanaka H. Disability and patient's appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan. Mod Rheumatol 2006;16(3):151-7. PubMed PMID: 16767553.
8. Tanaka E, Inoue E, Kawaguchi Y, Tomatsu T, Yamanaka H, Hara M, Kamatani N. Acceptability and usefulness of mizoribine in the management of rheumatoid arthritis in methotrexate-refractory patients and elderly patients, based on analysis of data from a large-scale observational cohort study. Mod Rheumatol 2006;16(4):214-9. PubMed PMID: 16906370.
9. Ikari K, Momohara S, Nakamura T, Hara M, Yamanaka H, Tomatsu T, Kamatani N. Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis. Ann Rheum Dis 2006;65(5):671-3. PubMed PMID: 16176992.
10. Kajiyama H, Akama H, Yamanaka H, Shoji A, Matsuda Y, Tanaka E, Nakajima A, Terai C, Hara M, Tomatsu T, Saitoh T, Kamatani N. One third of Japanese patients with rheumatoid arthritis use complementary and alternative medicine. Mod Rheumatol 2006;16(6):355-9. PubMed PMID: 17164996.
11. Iwatani M, Inoue E, Nakamura T, Nakajima A, Hara M, Tomatsu T, Kamatani N, Yamanaka H. Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA. Mod Rheumatol 2006;16(6):376-80. PubMed PMID: 17165000.
12. Iwamoto T, Ikari K, Nakamura T, Kuwahara M, Toyama Y, Tomatsu T, Momohara S, Kamatani N. Association between PADI4 and rheumatoid arthritis: a meta-analysis. Rheumatology (Oxford) 2006 Jul;45(7):804-7. PubMed PMID: 16449362.
13. Ikari K, Momohara S, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N. Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population. Rheumatology (Oxford) 2006;45(11):1345-8. PubMed PMID: 16690758.
14. Yamada T, Nakajima A, Inoue E, Tanaka E, Hara M, Tomatsu T, Kamatani N, Yamanaka H. Increased risk of tuberculosis in patients with rheumatoid arthritis in Japan. Ann Rheum Dis 2006;65(12):1661-3. PubMed PMID: 16837491.
2007年
15. Furuya T, Kotake S, Inoue E, Nanke Y, Yago T, Kobashigawa T, Ichikawa N, Tanaka E, Momohara S, Nakajima A, Hara M, Tomatsu T, Yamanaka H, Kamatani N. Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study. J Rheumatol 2007;34(2):303-10. PubMed PMID: 17143973.
16. Iikuni N, Ikari K, Momohara S, Tomatsu T, Hara M, Yamanaka H, Okamoto H, Kamatani N. MHC2TA is associated with rheumatoid arthritis in Japanese patients. Ann Rheum Dis 2007;66(2):274-5. PubMed PMID: 17090564.
17. Yamanaka H, Inoue E, Tanaka E, Nakajima A, Taniguchi A, Terai C, Hara M, Tomatsu T, Kamatani N. Influence of methotrexate dose on its efficacy and safety in rheumatoid arthritis patients: evidence based on the variety of prescribing approaches among practicing Japanese rheumatologists in a single institute-based large observational cohort (IORRA). Mod Rheumatol 2007;17(2):98-105. PubMed PMID: 17437163.
18. Tanaka E, Kamitsuji S, Inoue E, Yamada T, Nakajima A, Takeuchi E, Yanagisawa A, Misaka R, Shigemoto M, Yamashita K, Imamura T, Hara M, Tomatsu T, Saito T, Lauren G, Triadafilopoulos G, Kamatani N, Singh G, Yamanaka H. Nonsteroidal anti-inflammatory drug use does not affect short-term endoscopic and histologic outcomes after Helicobacter pylori eradication in patients with rheumatoid arthritis. Mod Rheumatol 2007;17(3):228-34. PubMed PMID: 17564779.
19. Inoue E, Yamanaka H, Hara M, Tomatsu T, Kamatani N. Comparison of Disease Activity Score (DAS)28- erythrocyte sedimentation rate and DAS28- C-reactive protein threshold values. Ann Rheum Dis 2007;66(3):407-9. PubMed PMID: 16926186.
20. Koizumi K, Okamoto H, Kamitsuji S, Sato E, Suzuki K, Yamanaka H, Hara M, Tomatsu T, Kamatani N. The occurrence of Japanese cedar pollinosis with rheumatoid arthritis. Clin Exp Rheumatol 2007;25(3):505-6. PubMed PMID: 17631756.
21. Yamanaka H, Inoue E, Singh G, Tanaka E, Nakajima A, Taniguchi A, Hara M, Tomatsu T, Kamatani N. Improvement of disease activity of rheumatoid arthritis patients from 2000 to 2006 in a large observational cohort study IORRA in Japan. Mod Rheumatol 2007;17(4):283-9. PubMed PMID: 17694260.
22. Okamoto H, Koizumi K, Kamitsuji S, Inoue E, Hara M, Tomatsu T, Kamatani N, amanaka H. Beneficial action of statins in patients with rheumatoid arthritis in large observational cohort. J Rheumatol 2007;34(5):964-8. PubMed PMID: 17444591.
23. Shinozaki M, Inoue E, Nakajima A, Hara M, Tomatsu T, Kamatani N, Yamanaka H. Elevation of serum matrix metalloproteinase-3 as a predictive marker for the long-term disability of rheumatoid arthritis patients in a prospective observational cohort IORRA. Mod Rheumatol 2007;17(5):403-8. PubMed PMID: 17929133.
24. Iikuni N, Nakajima A, Inoue E, Tanaka E, Okamoto H, Hara M, Tomatsu T, Kamatani N, Yamanaka H. What's in season for rheumatoid arthritis patients? Seasonal fluctuations in disease activity. Rheumatology (Oxford) 2007;46(5):846-8. PubMed PMID: 17264092.
25. Iikuni N, Kobayashi S, Ikari K, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S. ITGAV polymorphism and disease susceptibility in a Japanese rheumatoid arthritis population. Arthritis Res Ther 2007;9(5):405. PubMed PMID: 17980054.
26. Momohara S, Inoue E, Ikari K, Kawamura K, Tsukahara S, Mochizuki T, Toki H, Miyawaki M, Saito S, Hara M, Kamatani N, Yamanaka H, Tomatsu T. Risk factors for total knee arthroplasty in rheumatoid arthritis. Mod Rheumatol 2007;17(6):476-80. PubMed PMID: 18084699.
27. Iwamoto T, Ikari K, Inoue E, Toyama Y, Hara M, Yamanaka H, Tomatsu T, Momohara S, Kamatani N. Failure to confirm association between PDCD1 polymorphisms and rheumatoid arthritis in a Japanese population. J Hum Genet 2007;52(6):557-60. PubMed PMID: 17468813.
2008年
28. Tsukahara S, Shinozaki M, Ikari K, Mochizuki T, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S. Effect of matrix metalloproteinase-3 functional SNP on serum matrix metalloproteinase-3 level and outcome measures in Japanese RA patients. Rheumatology (Oxford) 2008;47(1):41-4. PubMed PMID: 18077489.
29. Tsukahara S, Iwamoto T, Ikari K, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S. CTLA-4 CT60 polymorphism is not an independent genetic risk marker of rheumatoid arthritis in a Japanese population. Ann Rheum Dis 2008;67(3):428-9. PubMed PMID: 18292106.
30. Nishimoto K, Ikari K, Mochizuki T, Tomatsu T, Toyama Y, Hara M, Yamanaka H, Kamatani N, Momohara S. Lack of association between PADI4 and functional severity in Japanese rheumatoid arthritis patients. Ann Rheum Dis 2008;67(3):431-2. PubMed PMID: 18292109.
31. Iikuni N, Inoue E, Tanaka E, Hara M, Tomatsu T, Kamatani N, Yamanaka H. Low disease activity state with corticosteroid may not represent 'true' low disease activity state in patients with rheumatoid arthritis. Rheumatology (Oxford) 2008;47(4):519-21. PubMed PMID: 18356177.
32. Furuya T, Kotake S, Inoue E, Nanke Y, Yago T, Hara M, Tomatsu T, Kamatani N, Yamanaka H. Risk factors associated with incident fractures in Japanese men with rheumatoid arthritis: a prospective observational cohort study. J Bone Miner Metab 2008;26(5):499-505. PubMed PMID: 18758909.
33. Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum 2008;58(7):1940-6. PubMed PMID: 18576330.
34. Tanaka E, Mannalithara A, Inoue E, Hara M, Tomatsu T, Kamatani N, Singh G, Yamanaka H. Efficient management of rheumatoid arthritis significantly reduces long-term functional disability. Ann Rheum Dis 2008;67(8):1153-8. PubMed PMID: 17971459.
35. Momohara S, Inoue E, Ikari K, Tsukahara S, Kawamura K, Toki H, Hara M, Kamatani N, Yamanaka H, Tomatsu T. Risk factors for wrist surgery in rheumatoid arthritis. Clin Rheumatol 2008;27(11):1387-91. PubMed PMID: 18500434.
36. Tsukahara S, Ikari K, Sato E, Yamanaka H, Hara M, Tomatsu T, Momohara S, Kamatani N. A polymorphism in the gene encoding the Fcgamma IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis. Ann Rheum Dis 2008;67(12):1791-2. PubMed PMID: 19005160.
2009年
37. Yamanaka H. A cohort study of clinical care in rheumatoid arthritis: the IORRA study. JMAJ 2009;52(1):54-56.
38. Momohara S, Ikari K, Mochizuki T, Kawamura K, Tsukahara S, Toki H, Hara M, Kamatani N, Yamanaka H, Tomatsu T. Declining use of synovectomy surgery for patients with rheumatoid arthritis in Japan. Ann Rheum Dis 2009;68(2):291-2. PubMed PMID: 19139210.
39. Furuya T, Urano T, Ikari K, Kotake S, Inoue S, Hara M, Momohara S, Kamatani N, Yamanaka H. A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis. Mod Rheumatol 2009;19(2):140-6. PubMed PMID: 19023643.
40. Iikuni N, Sato E, Hoshi M, Inoue E, Taniguchi A, Hara M, Tomatsu T, Kamatani N, Yamanaka H. The influence of sex on patients with rheumatoid arthritis in a large observational cohort. J Rheumatol 2009;36(3):508-11. PubMed PMID: 19208610.
41. Urano W, Furuya T, Inoue E, Taniguchi A, Urano T, Kotake S, Sekita C, Inoue S, Hara M, Momohara S, Kamatani N, Yamanaka H. Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients. J Bone Miner Metab 2009;27(5):574-83. PubMed PMID: 19333678.
42. Saito S, Momohara S, Taniguchi A, Yamanaka H. The intra-articular efficacy of hyaluronate injections in the treatment of rheumatoid arthritis. Mod Rheumatol 2009;19(6):643-51. PubMed PMID: 19649562.
43. Furuya T, Yamagiwa K, Ikai T, Inoue E, Taniguchi A, Momohara S, Yamanaka H. Associated factors for falls and fear of falling in Japanese patients with rheumatoid arthritis. Clin Rheumatol 2009;28(11):1325-30. PubMed PMID: 19618097.
2010年
44. Tanaka E, Inoue E, Mannalithara A, Bennett M, Kamitsuji S, Taniguchi A, Momohara S, Hara M, Singh G, Yamanaka H. Medical care costs of patients with rheumatoid arthritis during the prebiologics period in Japan: a large prospective observational cohort study. Mod Rheumatol 2010;20(1):46-53. PubMed PMID: 19821162.
45. Momohara S, Inoue E, Ikari K, Kawamura K, Tsukahara S, Iwamoto T, Hara M, Taniguchi A, Yamanaka H. Decrease in orthopaedic operations, including total joint replacements, in patients with rheumatoid arthritis between 2001 and 2007: data from Japanese outpatients in a single institute-based large observational cohort (IORRA). Ann Rheum Dis 2010;69(1):312-3. PubMed PMID: 20007622.
46. Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S. Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. Ann Rheum Dis 2010;69(2):368-73. PubMed PMID: 19336421.
47. Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K. The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population. Arthritis Rheum 2010;62(2):574-9. PubMed PMID: 20112363.
48. Shidara K, Hoshi D, Inoue E, Yamada T, Nakajima A, Taniguchi A, Hara M, Momohara S, Kamatani N, Yamanaka H. Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA. Mod Rheumatol 2010;20(3):280-6. PubMed PMID: 20217173.
49. Nakajima A, Inoue E, Tanaka E, Singh G, Sato E, Hoshi D, Shidara K, Hara M, Momohara S, Taniguchi A, Kamatani N, Yamanaka H. Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA. Scand J Rheumatol 2010;39(5):360-367. PubMed PMID: 20476859.
50. Yano K, Ikari K, Inoue E, Tokita A, Sakuma Y, Hiroshima R, Iwamoto T, Kawakami K, Taniguchi A, Yamanaka H, Momohara S. Effect of total knee arthroplasty on disease activity in patients with established rheumatoid arthritis: 3-year follow-up results of combined medical therapy and surgical intervention. Mod Rheumatol 2010;20(5):452-7. PubMed PMID: 20490599.
51. Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet 2010;42(6):515-9. PubMed PMID: 20453841.
52. Kitahama M, Okamoto H, Koseki Y, Inoue E, Kaneko H, Taniguchi A, Momohara S, Yamanaka H. Efficacy and safety of tacrolimus in 101 consecutive patients with rheumatoid arthritis. Mod Rheumatol 2010;20(5):478-85. PubMed PMID: 20552247.
53. Yamagiwa K, Iijima S, Furuya T, Ikai T, Inoue E, Taniguchi A, Momohara S, Yamanaka H. Incidence of falls and fear of falling in Japanese patients with rheumatoid arthritis. Mod Rheumatol 2010;21(1):51-6. PubMed PMID: 20842405.
2011年
54. Nishimoto K, Ikari K, Kaneko H, Tsukahara S, Kochi Y, Yamamoto K, Nakamura Y, Toyama Y, Taniguchi A, Yamanaka H, Momohara S. Association of EMCN with susceptibility to rheumatoid arthritis in Japanese populations. J Rheumatol 2011;38(2):221-8. PubMed PMID 21159824.
55. Momohara S, Inoue E, Ikari K, Yano K, Tokita A, Suzuki T, Sakuma Y, Hiroshima R, Kawakami K, Masuda I, Iwamoto T, Taniguchi A, Yamanaka H. Efficacy of total joint arthroplasty in patients with established rheumatoid arthritis: improved longitudinal effects on disease activity but not on health-related quality of life. Mod Rheumatol 2011;21(5):476-81. PubMed PMID: 21373798.
56. Seto Y, Tanaka E, Inoue E, Nakajima A, Taniguchi A, Momohara S, Yamanaka H. Studies of the efficacy and safety of methotrexate at dosages over 8 mg/week using the IORRA cohort database. Mod Rheumatol 2011;21(6):579-593. [Epub ahead of print] PubMed PMID: 21424533.
57. Furuya T, Hosoi T, Saito S, Inoue E, Taniguchi A, Momohara S, Yamanaka H. Fracture risk assessment and osteoporosis treatment disparities in 3,970 Japanese patients with rheumatoid arthritis.Clin Rheumatol 2011;30(8):1105-11. PubMed PMID: 21484222.
58. Nakajima A, Inoue E, Shidara K, Hoshi D, Sato E, Seto Y, Tanaka E, Taniguchi A, Momohara S, Yamanaka H. Standard treatment in daily clinical practice for early rheumatoid arthritis improved disease activity from 2001 to 2006. Mod Rheumatol 2011;21(6):594-597. PubMed PMID: 21516373.
59. Yamada T, Nakajima A, Inoue E, Tanaka E, Taniguchi A, Momohara S, Yamanaka H. Incidence of malignancy in Japanese patients with rheumatoid arthritis. Rheumatol Int 2011;31(11):1487-92. PubMed PMID: 20473757.
60. Terao C, Ohmura K, Kochi Y, Ikari K, Maruya E, Katayama M, Shimada K, Murasawa A, Honjo S, Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara S, Yamanaka H, Yamada R, Saji H, Matsuda F, Mimori T. A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects. Ann Rheum Dis 2011;70 (12):2134-9. PubMed PMID:21873689.
2012年
61. Hoshi D, Nakajima A, Inoue E, Shidara K, Sato E, Kitahama M, Seto Y, Tanaka E, Urano W, Ichikawa N, Koseki Y, Momohara S, Taniguchi A, Yamanaka H. Incidence of serious respiratory infection in patients with rheumatoid arthritis treated with tocilizumab. Mod Reumatol 2012;22(1):122-7. PubMed PMID:21735355.
62. Shidara K, Inoue E, Hoshi D, Sato E, Nakajima A, Momohara S, Taniguchi A, Yamanaka H. Anti-cyclic citrullinated peptide antibody predicts functional disability in patients with rheumatoid arthritis in a large prospective observational cohort in Japan. Rheumatol Int 2012;32(2):361-6. PubMed PMID: 21113712.
63. Momohara S, Inoue E, Ikari K, Yano K, Tokita A, Honjo Y, Sakuma Y, Hiroshima R, Iwamoto T, Seto Y, Tanaka E, Taniguchi A, Yamanaka H. Comparison of characteristics and therapeutic efficacy in rheumatoid arthritis patients treated by rheumatologists and those treated by orthopedic surgeons under a team medicine approach at the same institute. Mod Rheumatol 2012;22(2):209-15. PubMed PMID: 21761229.
64. Tanaka E, Mannalithara A, Inoue E, Iikuni N, Taniguchi A, Momohara S, Singh G, Yamanaka H. Effects of long-term corticosteroid usage on functional disability in patients with early rheumatoid arthritis, regardless of controlled disease activity. Rheumatol Int 2012;32(3):749-57. PubMed PMID: 21161535.
65. Shidara K, Inoue E, Hoshi D, Tanaka E, Seto Y, Nakajima A, Momohara S, Taniguchi A, Yamanaka H. The influence of individual joint impairment on functional disability in rheumatoid arthritis using a large observational database of Japanese patients. J Rheumatol 2012;39(3):476-80. PubMed PMID:22247366.
66. Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genetics 2012;44(5):511-6. PubMed PMID:22446963.
67. Terao C, Ikari K, Ohmura K, Suzuki T, Iwamoto T, Takasugi K, Saji H, Taniguchi A, Momohara S, Yamanaka H, Matsuda F, Mimori T. Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis: no strong genetic impact of shared epitope to ACPA levels after stratification of HLA-DRB1*09:01. Ann Rheum Dis 2012;71(6):1095-7. PubMed PMID:22233603.
68. Terao C, Ohmura K, Ikari K, Kochi Y, Maruya E, Katayama M, Yurugi K, Shimada K, Murasawa A, Honjo S, Takasugi K, Matsuo K, Tajima K, Suzuki A, Yamamoto K, Momohara S, Yamanaka H, Yamada R, Saji H, Matsuda F, Mimori T. ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese. PLoS One 2012;7(7):e40067. PubMed PMID:22792215.
69. Momohara S, Ikari K, Kawakami K, Iwamoto T, Inoue E, Yano K, Sakuma Y, Hiroshima R, Tokita A, Taniguchi A, Yamanaka H. The increasing disease duration of patients at the time of orthopaedic surgery for rheumatoid arthritis. Rheumatol Int 2012;32(10):3323-4. PubMed PMID: 21898065.
70. Myouzen K, Kochi Y, Okada Y, Terao C, Suzuki A, Ikari K, Tsunoda T, Takahashi A, Kubo M, Taniguchi A, Matsuda F, Ohmura K, Momohara S, Mimori T, Yamanaka H, Kamatani N, Yamada R, Nakamura Y, Yamamoto K. Functional variants in NFKBIE and RTKN2 involved in activation of the NF-kappaB pathway are associated with rheumatoid arthritis in Japanese. PLoS Genet 2012;8(9)e1002949. PMID:23028356.
2013年
71. Suzuki T, Ikari K, Kawaguchi Y, Yano K, Iwamoto T, Kawamoto M, Toyama Y, Taniguchi A, Yamanaka, H, Momohara S. Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility in Japanese rheumatoid arthritis patients. Mod Rheumatol 2013;23(1):200-2. PubMed PMID:22350639.
72. Yamanaka H, Seto Y, Tanaka E, Furuya T,, Nakajima A, Ikari K, Taniguchi A, Momohara S. Management of rheumatoid arthritis: the 2012 perspective. Mod Rheumatol 2013;23(1):1-7. PubMed PMID:22772460.
73. Ochi K, Furuya T, Ikari K, Taniguchi A, Yamanaka H, Momohara S. Sites, frequencies, and causes of self-reported fractures in 9,720 rheumatoid arthritis patients: a large prospective observational cohort study in Japan. Arch Osteoporos 2013;8(1-2):130. PMID:23526031.
74. Sato E, Nishimura K, Nakajima A, Okamoto H, Shinozaki M, Inoue E, Taniguchi A, Momohara S, Yamanaka H. Major depressive disorder in patients with rheumatoid arthritis. Mod Rheumatol 2013;23(2):237-44. PubMed PMID:22618411.
75. Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K, Terao C, Okada Y, Wedrén S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F, Mimori T, Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet ME, Tak PP, Crusius JB, van der Horst-Bruinsma IE, Wolbink GJ, va Riel PL, van de Laar M, Guchelaar HJ, Shadick NA, Allaart CF, Huizinga TW, Toes RE, Kimberly RP, Bridges SL Jr, Criswell LA, Moreland LW, Fonseca JE, de Vries N, Stranger BE, De Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK, Mariette X, Baron A, Padyukov L, Coenen MJ, Karlson EW, Plenge RM. Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. PLoS Genet 2013 Mar;9(3):e1003394. PMID:23555300.
76. Tanaka E, Hoshi D, Igarashi A, Inoue E, Shidara K, Sugimoto N. Sato, E, Seto Y, Nakajima A, Momohara S, Taniguchi A, Tsutani K, Yamanaka H. Analysis of direct medical and nonmedical costs for care of rheumatoid arthritis patients using the large cohort database, IORRA. Mod Rheumatol 2013;23(4):742-51. PubMed PMID:22878927.
77. Kitahama M, Nakajima A, Inoue E, Taniguchi A, Momohara S, Yamanaka H. Efficacy of adjunct tacrolimus treatment in patients with rheumatoid arthritis with inadequate responses to methotrexate. Mod Rheumatol 2013;23(4):788-93. PubMed PMID: 22975732.
78. Suzuki T, Ikari K, Yano K, Inoue E, Toyama Y, Taniguchi A, Yamanaka H, Momohara S. PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. PLoS One 2013;8(4):e61045. PMID:23577190.
79. Furuya T, Inoue E, Hosoi T, Taniguchi A, Momohara S, Yamanaka H. Risk factors associated with the occurrence of hip fracture in Japanese patients with rheumatoid arthritis: a prospective observational cohort study. Osteoporos Int 2013;24(4):1257-65. PubMed PMID:22801953.
80. Nakajima A, Saito K, Kojima T, Amano K, Yoshio T, Fukuda W, Inoue E, Taniguchi A, Momohara S, Minota S, Takeuchi T, Ishiguro N, Tanaka Y, Yamanaka H. No increased mortality in patients with rheumatoid arthritis treated with biologics: results from the biologics register of six rheumatology institutes in Japan. Mod Rheumatol 2013 Sept;23(5):945-52. PubMed PMID: 23073692.
81. Seto Y, Inoue E, Shidara K, Hoshi D, Sugimoto N, Sato E, Tanaka E, Nakajima A, Taniguchi A, Momohara S, Yamanaka H. Functional disability can deteriorate despite suppression of disease activity in patients with rheumatoid arthritis: a large observational cohort study. Mod Rheumatol 2013 Nov;23(6):1179-85. PubMed PMID:23319067.
82. Furuya T, Hosoi T, Tanaka E, Nakajima A, Taniguchi A, Momohara S, Yamanaka H. Prevalence of and factors associated with vitamin D deficiency in 4,793 Japanese patients with rheumatoid arthritis. Clin Rheumatol 2013;32(7):1081-87. PubMed PMID:23423442.
83. Kobashigawa T, Nakajima A, Taniguchi A, Inoue E, Tanaka E, Momohara S, Yamanaka H. Vaccination against seasonal influenza is effective in Japanese patients with rheumatoid arthritis enrolled in a large observational cohort. Scand J Rheumatol 2013;42(6):445-50. PubMed PMID:23724971.
2014年
84. Yamanaka H, Sugiyama N, Inoue E, Taniguchi A, Momohara S. Estimates of the prevalence of and current treatment practices for rheumatoid arthritis in Japan using reimbursement data from health insurance societies and the IORRA cohort(1). Mod Rheumatol 2014 Jan;24(1):33-40. PubMed PMID:24261756.
85. Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariiette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; RACI consortium; Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Berhrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014 Feb 20;506(7488):376-81. PubMed PMID:24390342.
86. Yoshida S, Ikari K, Furuya T, Toyama Y, Taniguchi A, Yamanaka H, Momohara S. A GC polymorphism associated with serum 25-hydroxyvitamin D level is a risk factor for hip fracture in Japanese patients with rheumatoid arthritis: 10-year follow-up of the Institute of Rheumatology, rheumatoid arthritis cohort study. Arthritis Res Ther 2014 Mar 20;16(2):R75. PubMed PMID:24646907.
87. Ochi K, Go Y, Furuya T, Ikari K, Taniguchi A, Yamanaka H, Momohara S. Risk factors associated with the occurrence of distal radius fractures in Japanese patients with rheumatoid arthritis: a prospective observational cohort study. Clin Rheumatol 2014;33(4):477-83. PubMed PMID:24196989.
88. Yoshida S, Ikari K, Yano K, Toyama Y, Taniguchi A, Yamanaka H, Momohara S. Lack of association between IL-15 genetic variants and progression of joint destruction in Japanese patients with rheumatoid arthritis. Ann Rheum Dis 2014 ;73(4):784-5. PubMed PMID:2473077.
89. Momohara S, Inoue E, Ikari K, Ochi K, Ishida O, Yano K, Sakuma Y, Yoshida S, Koyama T, Koenuma N, Taniguchi A, Yamanaka H. Recent trends in orthopedic surgery aiming to improve quality of life for those with rheumatoid arthritis: data from a large observational cohort. J Rheumatol 2014;41(5):862-6. PubMed PMID:24692532.
90. Ikari K, Yano K, Yoshida S, Taniguchi A, Yamanaka H, Momohara S. Response to 'Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study'. Arthritis Res Ther 2014 Aug 27;16(5):422. PubMed PMID: 25263166.
91. Yoshida S, Ikari K, Furuya T, Toyama Y, Taniguchi A, Yamanaka H, Momohara S. An osteoprotegerin gene polymorphism is associated with an increased risk of hip fracture in Japanese patients with rheumatoid arthritis: results from the IORRA Observational Cohort Study. PLoS One 2014 Aug8;9(8):e104587. PubMed PMID: 25105978.
92. Terao C, Ohmura K, Ikari K, Kawaguchi T, Takahashi M, Setoh K, Nakayama T, Kosugi S, Sekine A, Tabara Y, Taniguchi A, Momohara S, Yamanaka H, Yamada R, Matsuda F, Mimori T; Nagahama Study Group. Effects of smoking and shared epitope on the production of anti-citrullinated Peptide antibody in a Japanese adult population. Arthritis Care Res (Hoboken). 2014 Dec;66(12):1818-27. PubMed PMID: 24942650.
2015年
93. Miyamae T, Tanaka E, Kishi T, Matsuyama T, Igarashi T, Fujikawa S, Taniguchi A, Momohara S,Yamanaka H. Long-term outcome of 114 adult JIA patients in a non-pediatric rheumatology institute in Japan. Mod Rheumatol 2015 Jan;25(1):62-6. PubMed PMID: 25019624.
94. Ochi K, Iwamoto T, Saito A, Ikari K, Toyama Y, Taniguchi A, Yamanaka H, Momohara S. Construct validity, reliability, response rate, and association with disease activity of the quick disabilities of the arm, shoulder and hand questionnaire in the assessment of rheumatoid arthritis. Mod Rheumatol 2015 Mar;25(2);241-5. PubMed PMID: 25065918.
95. Nakajima A, Inoue E, Shimizu Y, Kobayashi A, Shidara K, Sugimoto N, Seto Y, Tanaka E, Taniguchi A, Momohara S, Yamanaka H. Presence of comorbidity affects both treatment strategies and outcomes in disease activity, physical function, and quality of life in patients with rheumatoid arthritis. Clin Rheumatol 2015 Mar;34(3):441-9. PubMed PMID: 25073613.
96. Ochi K, Inoue E, Furuya T, Ikari K, Toyama Y, Taniguchi A, Yamanaka H, Momohara S. Ten-year incidences of self-reported non-vertebral fractures in Japanese patients with rheumatoid arthritis: discrepancy between disease activity control and the incidence of non-vertebral fracture. Osteoporos Int 2015 Mar;26(3):961-8. PubMed PMID: 25294026.
97. Sato E, Tanaka E, Ochiai M, Shimizu Y, Kobayashi A, Shidara K, Hoshi D, Sugimoto N, Inoue E, Seto Y, Nakajima A, Taniguchi A, Momohara S, Yamanaka H. Chronological changes in baseline disease activity of patients with rheumatoid arthritis who received biologic DMARDs between 2003 and 2012. Mod Rheumatol 2015 May;25(3)350-7. PubMed PMID: 25619283.
98. Ishida O, Furuya T, Inoue E, Ochi K, Ikari K, Taniguchi A, Yamanaka H, Momohara S. Risk factors for established vertebral fractures in Japanese patients with rheumatoid arthritis: Results from a large prospective observational cohort study. Mod Rheumatol 2015 May25(3):373-8. PubMed PMID: 25797805.
99. Nakajima A, Urano W, Inoue E, Taniguchi A, Momohara S, Yamanaka H. Incidence of herpes zoster in Japanese patients with rheumatoid arthritis from 2005 to 2010. Mod Rheumatol 2015 Jul;25(4):558-61. doi: 10.3109/14397595.2014.984829. PubMed PMID: 25648973.
100. Sato E, Tanaka E, Nakajima A, Inoue E, Shimizu Y, Yamaguchi R, Ochiai M, Shidara K, Hoshi D, Sugimoto N, Seto Y, Taniguchi A, Momohara S, Yamanaka H. Assessment of the effectiveness of Golimumab 50-mg and 100-mg regimens in patients with rheumatoid arthritis in daily practice. Mod Rheumatol. 2015 Jul;25(4):528-33. doi: 10.3109/14397595.2014.995892. PubMed PMID:25536168.
101. Tanaka E, Inoue E, Hoshi D, Shimizu Y, Kobayashi A, Sugimoto N, Shidara K, Sato E, Seto, Y, Nakajima A, Momohara S, Taniguchi A, Yamanaka H. Cost-effectiveness of tocilizumab, a humanized anti-interleukin-6 (IL-6) receptor monoclonal antibody, versus methotrexate in patients with rheumatoid arthritis using real-world data from the IORRA observational cohort study. Mod Rheumatol. 2015 Jul;25(4):503-13. doi: 10.3109/14397595.2014.1001475. PubMed PMID:25547018.
102. Terao C, Ohmura K, Kochi Y, Ikari K, Okada Y, Shimizu M, Nishina N, Suzuki A, Myouzen K, Kawaguchi T, Takahashi M, Takasugi K, Murasawa A, Mizuki S, Iwahashi M, Funahashi K, Natsumeda M, Furu M, Hashimoto M, Ito H, Fujii T, Ezawa K, Matsubara T, Takeuchi T, Kubo M, Yamada R, Taniguchi A, Yamanaka H, Momohara S, Yamamoto K, Mimori T, Matsuda F. Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares large proportion of susceptibility loci with ACPA-positive RA: -a meta-analysis of genome-wide association study in a Japanese population.Arthritis Res Ther. 2015 Apr 18;17:104. doi: 10.1186/s13075-015-0623-4. PubMed PMID:25927497.
103. Terao C, Yano K, Ikari K, Furu M, Yamakawa N, Yoshida S, Hashimoto M, Ito H, Fujii T, Ohmura K, Yurugi K, Miura Y, Maekawa T, Taniguchi A, Momohara S, Yamanaka H, Mimori T, Matsuda F. A main contribution of DRB1*04:05 among shared epitope and involvement of 57th DRB1 amino acid in association with joint destruction in ACPA(+) RA. Arthritis Rheumatol. 2015 May;67(8):2038-45. doi: 10.1002/art.39133. PubMed PMID:25777156.
104. Inoue Y, Nakajima A, Tanaka E, Inoue E, Kobayashi A, Hoshi D, Sugimoto N, Seto Y, Taniguchi A, Momohara S, Yamanaka H. Effect of Smoking on Remission Proportions Differs Between Male and Female Patients with Rheumatoid Arthritis: A Study Based on the IORRA Survey. J Rheumatol. 2015 Jul;42(7):1083-9. doi: 10.3899/jrheum.140376. PubMed PMID:25774060.
105. Terao C, Suzuki A, Ikari K, Kochi Y, Ohmura K, Katayama M, Nakabo S, Yamamoto N, Suzuki T, Iwamoto T, Yurugi K, Miura Y, Maekawa T, Takasugi K, Kubo M, Saji H, Taniguchi A, Momohara S, Yamamoto K, Yamanaka H, Mimori T, Matsuda F. An association between the 74th amino acid position of HLA-DRB1 and ACPA levels of Japanese ACPA-positive RA. Arthritis Rheumatol. 2015 May;67(8):2038-45. doi: 10.1002/art.39133. PubMed PMID:25832994.
106. Nyberg F, Askling J, Berglind N, Franzén S, Ho M, Holmqvist M, Horne L, Lampl K, Michaud K, Pappas DA, Reed G, Symmons D, Tanaka E, Tran TN, Verstappen SM, Wesby-van Swaay E, Yamanaka H, Greenberg JD. Using epidemiological registry data to provide background rates as context for adverse events in a rheumatoid arthritis drug development program: a coordinated approach. Pharmacoepidemiol Drug Saf 2015;24(11):1121-32. PubMed PMID:26303866.
107. Terao C, Yamakawa N, Yano K, Markusse IM, Ikari K, Yoshida S, Furu M, Hashimoto M, Ito H, Fujii T, Ohmura K, Murakami K, Takahashi M, Hamaguchi M, Tabara Y, Taniguchi A, Momohara S, Raychaudhuri S, Allaart CF, Yamanaka H, Mimori T, Matsuda F. Rheumatoid factor is associated with the distribution of hand joint destruction in rheumatoid arthritis. Arthritis Rheumatol 2015;67(12):3113-23. PubMed PMID:26245322.
108. Verstappen SM, Askling J, Berglind N, Franzen S, Frisell T, Garwood C, Greenberg JD, Holmqvist M, Horne L, Lampl K, Michaud K, Nyberg F, Pappas DA, Reed G, Symmons DP, Tanaka E, Tran TN, Yamanaka H, Ho M. Methodological challenges when comparing demographic and clinical characteristics of international observational registries. Arthritis Care Res (Hoboken) 2015;67(12):1637-45 . PubMed PMID:26201948.
2016年
109. Hoshi D, Tanaka E, Igarashi A, Inoue E, Kobayashi A, Sugimoto N, Shidara K, Sato E, Seto Y, Nakajima A, Momohara S, Taniguchi A, Tsutani K, Yamanaka H. Profiles of EQ-5D utility scores in the daily practice of Japanese patients with rheumatoid arthritis; Analysis of the IORRA database. Mod Rheumatol 2016;26(1):40-5. PubMed PMID:26052801.
110. Yano K, Ikari K, Takatsuki Y, Taniguchi A, Yamanaka H, Momohara S. Longer operative time is the risk for delayed wound healing after forefoot surgery in patients with rheumatoid arthritis. Mod Rheumatol 2016;26(2):211-5. PubMed PMID:26156044.
111. Ochi K, Furuya T, Ishibashi M, Watanabe M, Ikari K, Taniguchi A, Yamanaka H, Momohara S. Risk factors associated with the occurrence of proximal humerus fractures in patients with rheumatoid arthritis: a custom strategy for preventing proximal humerus fractures. Rheumatol Int 2016;36(2):213-9. PubMed PMID:26420406.
112. Ochi K, Furuya T, Ikari K, Taniguchi A, Yamanaka H, Momohara S. Association between serum vitamin D level and history of falls in elderly Japanese patients with rheumatoid arthritis. Mod Rheumatol 2016;26(3):460-2. PubMed PMID:26548891.
113. Nakajima A, Inoue E, Taniguchi A, Momohara S, Yamanaka H. Effectiveness of tacrolimus in comparison with methotrexate or biologics in propensity score-matched patients with rheumatoid arthritis. Mod Rheumaol 2016 Jun 2:1-8. [Epub ahead of print] PMID:26934454.
114. Kim K, Bang SY,Ikari K, Yoo DH,Cho SK, Choi CB, Sung YK, Kim TH, Jun JB, Kang YM, Suh CH, Shim SC, Lee SS, Lee J, Chung WT, Kim SK, Choe JY, Momohara S, Taniguchi A, Yamanaka H, Nath SK, Lee HS, Bae SC. Association-heterogeneity mapping identifies an Asian-specific association of the GTF211ocus with rheumatoid arthritis. Sci Rep 2016 Jun 8;6:27563.doi: 10.1038/srep27563. PMID27272985.
115. Furuya T, Maeda S, Momohara S, Taniguchi A, Yamanaka H. Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study. J Bone Miner Metab 2016 Jul 2. [Epub ahead of print] PMID:27372662.
116. Tanaka E, Inoue E, Yamaguchi R, Shimizu Y, Kobayashi A, Sugimoto N, Hoshi D, Shidara K, Sato E, Seto Y, Nakajima A, Momohara S, Taniguchi A, Yamanaka H. Pharmacoeconomic analysis of biological disease modifying antirheumatic drugs in patients with rheumatoid arthritis based on real-world data from the IORRA observational cohort study in Japan. Mod Rheumatol 2016 Jul 29:1-10. [Epub ahead of print]PMID:27472516.
117. Okada Y, Suzuki A, Ikari K, Terao C, Kochi Y Ohmura K, Higasa K, Akiyama M, Ashikawa K, Kanai M, Hirata J, Suita N, Teo YY, Xu H, Bae SC, Takahashi A, Momozawa Y, Matsuda K, Momohara S, Taniguchi A, Yamada R, Mimori T, Kubo M, Brown MA, Raychaudhuri S, Matsuda F, Yamanaka H, Kamatani Y, Yamamoto K. Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis. Am J Hum Genet 2016 Aug 4;99(2):366-74.doi:10.1016/j.ajhg.2016.06.019. PMID:27486778.
118. Terao C, Ikari K, Nakayamada S, Takahashi Y, Yamada R, Ohmura K, Hashimoto M, Furu M, Ito H, Fujii T, Yoshida S, Saito K, Taniguchi A, Momohara S, Yamanaka H, Mimori T, Matsuda F. A twin study of rheumatoid arthritis in the Japanese population. Mod Rheumatol 2016 Sep;26(5):685-9. PubMed PMID:26727555.
119. Askling J, Berglind N, Franzen S, Frisell T, Garwood C, Greenberg JD, Ho M, Holmqvist M, Horne L, Inoue E, Michaud K, Nyberg F, Pappas DA, Reed G, Tanaka E, Tran TN, Verstappen SM, Yamanaka H, Wesby-van Swaay E, Symmons D. How comparable are rates of malignancies in patients with rheumatoid arthritis across the world? A comparison of cancer rates, and means to optimise their comparability, in five RA registries. Ann Rheum Dis 2016 Oct;75(10):1789-96. PubMed PMID:26621482.
120. Michaud K, Berglind N, Franzén S, Frisell T, Garwood C, Greenberg JD, Ho M, Holmqvist M, Horne L, Inoue E, Nyberg F, Pappas DA, Reed G, Symmons D, Tanaka E, Tran TN, Verstappen SM, Wesbyvan Swaay E, Yamanaka H, Askling J. Can rheumatoid arthritis (RA) registries provide contextual safety data for modern RA clinical trials? The case for mortality and cardiovascular disease. Ann Rheum Dis 2016 Oct;75(10):1797-805. PubMed PMID:26857699.
121. Shidara K, Nakajima A, Inoue E, Hoshi D, Sugimoto N, Seto Y, Tanaka E, Ikari K, Taniguchi A, Yamanaka H. The minimally important dirrerence for the Japanese version of the health assessment questionnaire in patients with rheumatoid arthritis in daily practice. Mod Rheumatol 2016 Oct 21:1-5. [Epub ahead of print] PMID:27766911.
122. Shidara K, Nakajima A, Inoue E, Hoshi D, Sugimoto N, Seto Y, Tanaka E, Momohara S, Taniguchi A, Yamanaka H. Continual maintenance of remission defined by the ACR/EULAR criteria in daily practice leads to better functional outcomes in patients with rheumatoid arthritis. J Rheumatol 2016 Dec 1. pii:jrheum.160395. [Epub ahead of print] PMID:27909083.
2017年
122. Shimizu Y, Nakajima A, Inoue E, Shidara K, Sugimoto N, Seto Y, Tanaka E, Momohara S, Taniguchi A, Yamanaka H. Characteristics and risk factors of lymphoproliferative disorders among patients with rheumatoid arthritis concurrently treated with methotrexate: a nested case-control study of the IORRA cohort. Clin Rheumatol 2017;36(6):1237-45. PubMed PMID: 28455827.
123. Ishigaki K, Kochi Y, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, Yamaguchi K, Nagafuchi Y, Nakachi S, Kato R, Sakurai K, Shoda H, Ikari K, Taniguchi A, Yamanaka H, Miya F, Tsunoda T, Okada Y, Momozawa Y, Kamatani Y, Yamada R, Kubo M, Fujio K, Yamamoto K. Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis. Nat Genet 2017;49(7):1120-5. PubMed PMID: 28553958.
124. Tsuji H, Yano K, Furu M, Yamakawa N, Ikari K, Hashimoto M, Ito H, Fujii T, Yamamoto W, Ohmura K, Taniguchi A, Momohara S, Matsuda F, Allaart CF, Yamanaka H, Mimori T, Terao C. Time-averaged disease activity fits better joint destruction in rheumatoid arthritis. Sci Rep. 2017;19;7(1):5856. PubMed PMID: 28724913.
125. Kuramoto N, Ohmura K, Ikari K, Yano K, Furu M, Yamakawa N, Hashimoto M, Ito H, Fujii T, Murakami K, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Taniguchi A, Momohara S, Yamanaka H, Matsuda F, Mimori T, Terao C. Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis. Sci Rep 2017;31;7(1):6911. PubMed PMID: 28761166.
126. Shimizu Y, Tanaka E, Inoue E, Shidara K, Sugimoto N, Seto Y, Nakajima A, Momohara S, Taniguchi A, Yamanaka H. Reduction of methotrexate and glucocorticoids use after the introduction of biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis in daily practice based on the IORRA cohort. Mod Rheumatol 2017 Sept 14:1-7. [Epub ahead of print] PubMed PMID: 28880684.
127. Sugimoto N, Nakajima A, Inoue E, Shidara K, Yamashita H, Mimori A, Tokuda H, Seto Y, Tanaka E, Momohara S, Taniguchi A, Yamanaka H. Incidence of comprehensive hospitalization due to infection, cardiovascular disease, fractures, and malignancies in patients with rheumatoid arthritis. Rheumatol Int 2017;37(11):1871-8. PubMed PMID: 28884287.
128. Terao C, Okada Y, Ikari K, Kochi Y, Suzuki A, Ohmura K, Matsuo K, Taniguchi A, Kubo M, Raychaudhuri S, Yamamoto K, Yamanaka H, Kamatani Y, Mimori T, Matsuda F. Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibililty to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population. J Med Genet 2017;54(12):853-8. PubMed PMID: 29025870.
129. Yamanaka H. Askling J, Berglind N, Franzen S, Frisell T, Garwood C, Greenberg JD, Ho M, Holmqvist M, Novelli Horne L, Inoue E, Michaud K, Pappas DA, Reed G, Symmonds D, Tanaka E, Tran TN, Verstappen SMM, Wesby-van Swaay E, Nyberg F. Infection rates in patients from five rheumatoid arthritis (RA) registries: contextualizing an RA clinical trial programme. RMD open. 2017 Oct 10;3(2):e000498. doi: 10.1136/rmdopen-2017-000498. PMID: 29081988.
2018年
130. Hiwa R, Ikari K, Ohmura K, Nakabo, Matsuo K, Saji H, Yurugi K, Miura Y, Maekawa T, Taniguchi A, Yamanaka H, Matsuda F, Mimori T, Terao C. HLA-DRB1 analysis identified a genetically unique subset whthin rheumatoid arthritis and distinct genetic background of rheumatoid factor levels from anticyclic citrullinated peptide antibodies. J Rheumatol 2018;45(4):470-80. PubMed PMID: 29419463.
131. Yano K, Ikari K, Inoue E, Sakuma Y, Mochizuki T, Koenuma N, Tobimatsu H, Tanaka E, Taniguchi A, Okazaki K, Yamanaka H. Features of patients with rheumatoid arthritis whose debut joint is a foot or ankle joint: A 5,479-case study from the IORRA cohort. PLoS One 2018;13(9):e0202427.doi:10.1371/journal.pone.0202427.ecollection 2018. PubMed PMID: 30188930.
2019年
132. Nakayama M, Furuya T, Inoue E, Tanaka E, Ikari K, Nakajima A, Taniguchi A, Yamanaka H. Factors associated with decreasing serum 25(OH)D among Japanese patients with rheumatoid arthritis: Results from the IORRA cohort study. Mod Rheumatol 2019:29(3):430-5. doi:10.1080/14397595.2018.1481727. PubMed PMID: 29799293.
133. Tsuji H, Ikari K, Ohmura K, Yano K, Furu M, Hashimoto M, Ito H, Fujii T, Yamamoto W, Taniguchi A, Yamanaka H, Mimori T, Terao C. Significant joint-destructive association of HLA-DRB1*04:05 independent of DAS28 in rheumatoid arthritis. Ann Rheum Dis 2019;78(2):284-6. PubMed PMID: 30232193.
134. Sakaue S, Hirata J, Maeda Y, Kawakami E, Nii T, Kishikawa T, Ishigaki K, Terao C, Suzuki K, Akiyama M, Suita N, Masuda T, Ogawa K, Yamamoto K, Saeki Y, Matsushita M, Yoshimura M, Matsuoka H, Ikari K, Taniguchi A, Yamanaka H, Kawaji H, Lassmann T, Itoh M, Yoshitomi H, Ito H, Ohmura K, R Forrest AR, Hayashizaki Y, Carninci P, Kumanogoh A, Kamatani Y, de Hoon M, Yamamoto K, OkadaY. Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity. Nucleic Acids Res 2018;46(22):11898-909. PubMed PMMID: 30407537.
135. Furuya T, Inoue E, Tanaka E, Maeda S, Ikari K, Taniguchi A, Yamanaka H. Age and female gender associated with periodontal disease in Japanese patietns with rheumatoid arthritis: Results from self-reported questionnaires from the IORRA cohort study. Mod Rheumatol 2019:1-6. doi: 10.1080/14397595.2019.1621461. [Epub ahead of print] PMID:31116056.
136. Yamanaka H, Tanaka E, Nakajima A, Furuya T, Ikari K, Taniguchi A, Inoue E, Harigai M. A large observational cohort study of rheumatoid arthritis, IORRA: Providing context for today’s treatment options. Mod Rheumatol 2019 Oct 1:1-6. doi: 10.1080/14397595.2019.1660028.[Epub ahead of print] PMID:31475852.
文責 田中栄一
2020年4月14日更新
